These two enzymes are the most common plasmid-mediated beta-lactamases in gram-negative bacteria, including Enterobacteriaceae, Pseudomonas aeruginosa , Haemophilus influenzae , and Neisseria gonorrhoeae . TEM-1 and TEM-2 hydrolyze penicillins and narrow spectrum cephalosporins, such as cephalothin or cefazolin. However, they are not effective against higher generation cephalosporins with an oxyimino side chain, such as cefotaxime, ceftazidime, ceftriaxone, or cefepime. Consequently, when these antibiotics were first introduced, they were effective against a broad group of otherwise resistant bacteria. A related but less common enzyme was termed SHV, because sulfhydryl reagents had a variable effect on substrate specificity. (See "Beta-lactam antibiotics: Mechanisms of action and resistance and adverse effects" and "Cephalosporins" .)
Recent studies revealed that certain parents have felt anxious regarding violence in video games. Politics have started to recognize video games as an equal means of media entertainment and introduced ratings and limitations accordingly. Numerous researchers and agencies have begun to investigate the issue of violence in video games and how it affects child behavior. While the American Physiological Association decided that violent video games indeed provoke aggressive behavior, most researchers disagreed, calling the results of the association’s study as being full of flaws and unscientific.
Stromberg/Garrigan & Associates is a full service planning and design practice offering comprehensive landscape architecture, urban design and planning services primarily focused on the revitalization and redevelopment of communities. SGA specializes in the practice of “land recycling” and is a recognized leader in the reuse of formerly developed land including environmentally contaminated sites often referred to as brownfields. The firm employs a comprehensive and multi-disciplinary approach to all of our projects with the goal of providing the highest level of creativity in order to meet or exceed our clients' goals and expectations.